產(chǎn)品信息

MAPK屬于一種Ser/Thr蛋白激酶，可在多種不同的信號轉(zhuǎn)導途徑中充當一種共同的信號轉(zhuǎn)導成份，且在細胞周期調(diào)控中發(fā)揮重要的作用。MAPK信號通路包括：MAP激酶（MAPK）、MAPK激酶（MEK、MKK或MAPK 激酶）和MEK激酶（MEKK、MKKK或MAPK激酶激酶）。在哺乳動物機體中，已經(jīng)發(fā)現(xiàn)五種不同的MAPK信號轉(zhuǎn)導通路。其中ERK1/2信號轉(zhuǎn)導通路調(diào)控細胞生長和分化，JNK和p38 MAPK信號轉(zhuǎn)導通路在炎癥與細胞凋亡等應激反應中發(fā)揮重要作用。

PD 0325901:
A selective inhibitor against purified MEK, exhibiting a Ki of 1 nM against activated MEK1 and MEK2. It has been shown that 1 µM PD0325901 combined with 3 µM CHIR99021 (2i) prevents cell differentiation and sustains self-renewal of murine embryonic stem cells. N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE

Ref: Barret, S.D., Bridges, A.J., Dudley, D.T., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett 18 6501-6504, 2008. Ying, Q., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453 519-524, 2008.

Purity:
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.

重慶市華雅干細胞技術有限公司